Rev Esp Quimioter 2009:22(3):135-138

Activity of Ertapenem and Ceftriaxone in the eradication of Salmonella in a model of experimental peritonitis in mice

F. S. Lozano ,  M. I. García ,  E. García ,  B. González ,  M. B. García ,  F. J. García y J. E. García 

  

Since the beginning of the 1990s, the prevalence of isolates of non-typhoidal Salmonella species resistant to antimicrobial agents, including those commonly used for the treatment of Salmonella infections such as fluoroquinolones, trimethoprim-sulfamethoxazole or â-lactams, has increased substantially. Infections caused by multidrugresistant strains of non-typhoidal Salmonella are now frequently encountered. In order to consider an appropriate role of Ertapenem in Salmonella-due intraabdominal infections, in the present study we compare the efficacy of Ertapenem versus that of Ceftriaxone in a mouse peritonitis model. Bacteriological eradication from blood, liver and mesenteric lymph nodes was observed after 5 and 7 days of treatment in all infected mice receiving ceftriaxone. Although both antimicrobial agents —Ertapenem and Ceftriaxone— were observed to be effective in reducing mortality in inoculated mice, our data suggests a reduced efficacy of Ertapenem in the bacteriological eradication of Salmonella enterica serotype Typhimurium in a mouse peritonitis model.

  

Key words: Ceftriaxone. Ertapenem. Bacteriological eradication. Experimental peritonitis. 

Rev Esp Quimioter 2009:22(3):135-138 [pdf]