Rev Esp Quimioter 2009;22(1):25-29
In vitro activity of fosfomycin against ESBL-producing enterobacteria of urinary origin
M.ª S. Hernández , J. Á. García y J. L. Muñoz
In vitro activity of fosfomycin, compared with other antibiotics used for urinary tract infections (UTI), against extended spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates obtained from UTIs, was determined. The activity of fosfomycin, co-trimoxazole, ciprofloxacin, nitrofurantoin, amoxicillin/ clavulanic acid and gentamicin against 71 ESBL-producing E. coli clinical isolates and 13 ESBL producing K. pneumoniae clinical isolates obtained from UTI was studied by the agar-dilution method or E-test. E. coli isolates produced mainly CTX-M type ESBL (76.1%), especially CTX-M 14 (56.3 %). K. pneumoniae isolates produced most predominantly SHV-type ESBL (92.3%), mainly SHV-2 (76.9 %). Gentamicin (4.4 %), fosfomycin (5.6 %) and nitrofurantoin (5.6 %) showed the lowest resistance proportions against E. coli. Co-trimoxazole and ciprofloxacin (7.7 %) showed the lowest resistance proportions against K. pneumoniae.
Key words: Escherichia coli. Klebsiella pneumoniae. Extended spectrum beta-lactamase (ESBL). Fosfomycin.
Rev Esp Quimioter 2009;22(1):25-29 [pdf]