Rev Esp Quimioter 2015:28(2):86-91

Detection of unusual uropathogens during a period of three years in a regional hospital                                 
 


CRISTINA GÓMEZ-CAMARASA, CARMEN LIÉBANA-MARTOS, JOSÉ MARÍA NAVARRO-MARÍ, JOSÉ GUTIÉRREZ-FERNÁNDEZ              

 

Urinary tract infections (UTIs) are one of the most fre-quent both in the community and in hospitals infectious diseases. The etiology of urinary tract infections is well established but may vary depending on various factors such as age, the presence of underlying diseases such as diabetes, instrumental procedures such as urinary catheterization or exposure to antibiotics or previous hospitalizations.  UTIs diagnosed cases were retrospectively reviewed for unusual microorganisms over a period of 3 years (2011-2013) in the Microbiology Laboratory of the Hospital Virgen de las Nieves of Granada (Spain), following the standard operating procedure, which we describe four cases caused by Trichosporon asahii, Aerococcus urinae, Pasteurella bettyae and Neisseria sicca. Hence the importance of having in the Clinical Microbiology Laboratory of the tools necessary to detection UTIs and reach a correct identification in all cases.

Rev Esp Quimioter 2015:28(2):86-91 [pdf]

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Rev Esp Quimioter 2015:28(4):210-213

In vitro antifungal susceptibility profile of Scopulariopsis brevicaulis isolated from onychomycosis     

                        
ALFONSO JAVIER CARRILLO-MUÑOZ, CRISTINA TUR-TUR, DÉLIA CÁRDENES, FLORENCIA ROJAS, GUSTAVO GIUSIANO              

We studied the in vitro antifungal activity profile of amorolfine (AMR), bifonazole (BFZ), clotrimazole (CLZ), econazole (ECZ), fluconazole (FNZ), itraconazole (ITZ), ketoconazole (KTZ), miconazole (MNZ), oxiconazole (OXZ), tioconazole (TCZ) and terbinafine (TRB)  against 26 clinical isolates of Scopulariopsis brevicaulis from patients with onychomycosis by means of an standardized microdilution method. Although this opportunistic filamentous fungi was reported as resistant to several broad-spectrum antifungals agents, obtained data shows a better fungistatic in vitro activity of AMR, OXZ and TRB (0.08, 0.3, and 0.35 mg/L, respectively) in comparison to that of CLZ (0.47 mg/L), ECZ (1.48 mg/L), MNZ (1.56 mg/L, BFZ (2.8 mg/L), TCZ (3.33 mg/L), KTZ (3.73 mg/L). FNZ (178.47 mg/L) and ITZ (4.7 mg/L) showed a reduced in vitro antifungal activity against S. brevicaulis. Obtained MICs show the low in vitro antifungal susceptibility of S. brevicaulis to topical drugs for onychomycosis management, with exceptions (AMR, OZX and TRB).

Rev Esp Quimioter 2015:28(4):210-213 [pdf]

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Rev Esp Quimioter 2015:28(5):225-234

Noma/Cancrum oris: a neglected disease     

                        
MARÍA GARCÍA-MORO, ENRIQUE GARCÍA-MERINO, ÁNGEL MARTÍN-DEL-REY, ENRIQUE GARCÍA-SÁNCHEZ, JOSÉ ELÍAS GARCÍA- SÁNCHEZ              

Noma is an aggressive orofacial gangrenous pathology that damages hard and soft tissues of the mouth and the face. Throughout the centuries it has been present around the globe, but nowadays it has practically disappeared from developed countries and mainly affects children from the most disadvantaged places, especially in Africa. Noma disease is a multifactorial process; malnutrition, debilitating diseases (bacterial or viral systemic diseases, HIV-associated immunosuppression, etc.) and intraoral infections are some of the factors implied. The characteristic tissue necrosis is produced by a polymicrobial infection. Fusobacterium necrophorum, Prevotella intermedia, Prevotella melaninogenica, Fusobacterium nucleatum, Bacteroides fragilis, Bacillus cereus, Trueperella pyogenes, spyrochetes, etc, are some of the species that have been isolated from the affected areas. Without treatment, noma is lethal in a short period of time, and the patients that survive show severe sequelae that hinder their life and interpersonal relationships. The aim of this paper is to unify the existing information and to promote wider knowledge and awareness among the population.

Rev Esp Quimioter 2015:28(5):225-234 [pdf]

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