Rev Esp Quimioter 2017, 30(4):276-279

Outpatient parenteral antimicrobial therapy for infective endocarditis in patients over 80 years

XABIER KORTAJARENA, MIGUEL ÁNGEL GOENAGA, MAIALEN IBARGUREN, HARKAITZ AZKUNE, MARIA JESUS BUSTINDUY, ANA FUERTES, OIHANA IBARGUREN, MUSKILDA GOYENECHE, REBECA GARCIA, GAMEGI GROUP  HOSPITAL UNIVERSITARIO DONOSTIA

Introduction. The incidence of infective endocarditis is progressively increasing, especially in elderly patients. Outpatient parenteral antibiotic therapy (OPAT) is being an excellent alternative for treatment, but advanced age is one of the relative contraindications. The aim of this study is to compare the characteristics and prognosis of patients less or more than 80 years, treated with OPAT.
Material and methods. One hundred and ninety four pa-tients were included between 1996 and 2015, 31 of them older than 80 years.
Results. The most frequently affected valve is the aortic one, mainly native valves. Most used antibiotics are ceftriaxone, ampicillin, cloxacillin and daptomycin. Differences in surgery (39.9% vs 9.7%, p=0.001) and use of infusion pump (55.2% vs 35.5%; p= 0.044) were observed, under 80 years and older respectively. No differences in readmissions and mortality were observed.
Conclusions. OPAT could be considered an effective alternative for appropriately-selected elderly patients with infective endocarditis.

Rev Esp Quimioter 2017; 30(4):276-279  [pdf]