Formulaciones liposómicas de anfotericina B: diferencias basadas en la evidencia científica JOSÉ RAMÓN AZANZA, BELÉN SÁDABA, JOANA REIS Este artículo presenta una visión general de las características de los liposomas como vehículos portadores de fármacos, especialmente en relación con las formulaciones liposómicas de anfotericina B. Se describen los aspectos generales relativos a la estructura de […]
Identification and in vitro antifungal susceptibility of vaginal Candida spp. isolates to fluconazole, clotrimazole, and nystatin MARIA CRISTINA DIAZ, ROSSANNA CAMPONOVO, INGRID ARAYA, ANN CERDA, MARÍA PAOLA SANTANDER, ALFONSO-JAVIER CARRILLO-MUÑOZ Objective. The aim of this study was to identify and determine the in vitro antifungal susceptibility testing to clotrimazole, fluconazole, and nystatin of 145 clinical […]
Liposomal formulations of amphotericin B: differences according to the scientific evidence JOSÉ RAMÓN AZANZA, BELÉN SÁDABA, JOANA REIS This article presents an overview of the characteristics of liposomes as drug carriers, particularly in relation to liposomal formulations of amphotericin B. General features regarding structure, liposome-cell interactions, stability, encapsulation of active substances and elimination of liposomes […]
Prosthetic joint infection in patients with hip fracture. Differences from infection of elective prosthesis JOSÉ Mª BARBERO, EDUARDO MONTERO, ALFONSO VALLÉS, MIGUEL ÁNGEL PLASENCIA, JUAN ROMANYK, JOAQUÍN LÓPEZ Introduction. Most publications about prosthetic joint infections (PJI) are referred to elective prosthesis and they exclude arthroplasties due to hip fracture.Methods. We conducted a descriptive study about […]
La utilidad clínica de los derivados triazólicos en el tratamiento de las infecciones fúngicas ALFONSO JAVIER CARRILLO-MUÑOZ, GUSTAVO GIUSIANO, ALICIA ARECHAVALA, CRISTINA TUR-TUR, ELENA ERASO, NEREA JAUREGIZAR, GUILLERMO QUINDÓS, RICARDO NEGRONI El tratamiento de las infecciones producidas por hongos se limita al uso de un reducido número de moléculas. Si bien, la anfotericina B aún […]
Potential antimicrobial drug interactions in clinical practice: consequences of polypharmacy and multidrug resistance CRISTINA MARTÍNEZ-MÚGICA Background. Polypharmacy is a growing problem nowadays, which can increase the risk of potential drug interactions, and result in a loss of effectiveness. This is particularly relevant to the antiinfective therapy, especially when infection is produced by resistant bacteria, because […]
Microbiology, antibiotic susceptibility, and bacteraemia associated factors in acute prostatitis CARLES FERRÉ, FERRÁN LLOPIS, JAVIER JACOB Introduction. The aim of the study was to analyze the characteristics of patients with acute prostatitis presenting to the Emergency Department, the microbiological findings, antibiotic susceptibility, and bacteraemia associated factors.Methods. Observational and cohort study with prospective follow-up including […]
Analysis of the concordance of antibiotic treatment for patients with severe sepsis in emergencies MARÍA ANTONIA PÉREZ-MORENO, BEATRIZ CALDERÓN-HERNANZ, BERNARDINO COMAS-DÍAZ, JORDI TARRADAS-TORRAS, MARCIO BORGES-SA Objectives. Antibiotic treatment is vital in patients with severe sepsis/septic shock. The objectives were to assess the degree of concordance between antibiotic prescribed in emergencies and post requirements; to relate […]
How should we approach Aspergillus in lung secretions of patients with COPD? JOSÉ BARBERÁN, FRANCISCO JAVIER CANDEL, ANA ARRIBI Aspergillus spp. is frequently isolated in respiratory samples from patients with severe COPD; however, the clinical significance of this mold is unclear and its presence may indicate temporary passage, benign chronic carriage, or onset of […]
Características clínicas y evolución de la neumonía por aspiración en octogenarios y nonagenarios ingresados en una Unidad de Medicina Interna General HÉCTOR PINARGOTE, JOSE MANUEL RAMOS, ALINA ZURITA, JOAQUÍN PORTILLA Introducción. La neumonía es una causa de elevada morbilidad y mortalidad en las personas de edad avanzada. La aspiración como una causa de neumonía es […]
