Rev Esp Quimioter 2008;21(3):198-202
Why not revisiting tinidazole as potential treatment of odontogenic infections?
F. Manso , M. S. Gamboa , M. J. Giménez , A. Bascones , M. L. Gómez-Lus , L. Aguilar
Tinidazole is a 5-nitroimidazole initially introduced into clinical medicine in 1969 for the treatment of unicellular parasites. Tinidazole offers selective bactericidal activity, not influenced by the inoculum size, against anaerobic bacteria, that make it of theoretical interest against periodontopathogen infections. This article reviews the required characteristics of an antibiotic directed to odontogenic anaerobic infections, as well as the pharmacodynamic pitfalls of common antibiotic treatments. In addition the in vitro, pharmacokinetic and pharmacodynamic properties of tinidazole are reviewed, assessing the degree of its adhesion to the required characteristics, as well as identifying the gaps to be fulfilled prior to its use in this medical field. Tinidazole offers interesting characteristics making worthy investigations as a candidate for the treatment of anaerobic odontogenic infections.
Key words: Tinidazole. Odontogenic infections. Odontopathogens. Pharmacodynamia.
Rev Esp Quimioter 2008;21(3):198-202 [pdf]