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Rev Esp Quimioter 2021; 34(2): 93-99

High level of medication regimen complexity index correlate with worse quality of life in people living with HIV

ENRIQUE CONTRERAS-MACÍAS, ANTONIO GUTIÉRREZ- PIZARRAYA, MARÍA AGUAS ROBUSTILLO-CORTÉS, RAMÓN MORILLO-VERDUGO

Published: 27 January 2021

http://www.doi.org/10.37201/req/097.2020

Objectives. People living with HIV (PLWHIV) have now a near-normal life expectancy and thus, a higher risk of polypharmacy. The main objective was to assess the correlation between medication regimen complexity index (MRCI) and quality of life (EQ-5D) and health utilities among PLWHIV patients on ART.
Patients and methods. Observational prospective single-center study including adult PLWHIV on ART from January to March-2020 attended at hospital pharmacy outpatient service according to a Capacity-Motivation-Opportunity (CMO) pharmaceutical care model.
Results. A total of 428 patients were included, mean age of 50 ± 10.9 years, 82.2% males. Negative correlation (r2=−0.147; p= 0.0002) between MRCI and EQ-5D was found. Relationship between the comorbidity pattern and quality of life, was also observed. Regarding MRCI, Anxiety/Depression, Pain/discomfort and Self-Care were the dimensions with the worst assessment.
Conclusions. A new multidimensional revised care plan for PLWHIV focussed on optimising overall patient care, not limited to viral load goal achievement alone but also in their pharmacotherapeutic complexity and quality of life is needed.

Rev Esp Quimioter 2021; 34(2): 93-99 [Full-text PDF]


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Rev Esp Quimioter 2021; 34(2): 107-114

Variability between health areas in antibiotic consumption among pediatric outpatients of Principado de Asturias, Spain (2005-2018)

LAURA CALLE-MIGUEL, GRACIA MODROÑO RIAÑO, ANA ISABEL IGLESIAS CARBAJO, MARÍA AGUSTINA ALONSO ÁLVAREZ, CELIA VICENTE MARTÍNEZ, GONZALO SOLÍS SÁNCHEZ

Published: 26 January 2021

http://www.doi.org/10.37201/req/108.2020

Background. Antibiotics in Spain are mainly prescribed in the community sector, remarking a high variability between areas. The aim of this study is to describe the variability between health areas in the antibiotic consumption in the pediatric population of Asturias during 2005-2018 period.
Methods. Retrospective and comparative study using data about consumption of antibacterial agents for systemic use (J01C group in ATC, Anatomical Therapeutic Chemical, classification) in the pediatric outpatients of the eight health areas of Principado de Asturias between 2005 and 2018, based on defined daily dose (DDD) per 1000 inhabitants and day (DID).
Results. Mean antibiotic consumption in pediatric outpatients in Principado de Asturias (2005-2018) was 14 DID (CI95% 13.4 – 14.6). Consumption increased until 2009 (15.2 DID) and decreased from 2015 onwards (11.9 DID in 2018). β-lactam penicillins was the most consumed therapeutic group (10.7 DID). There were statistically significant differences among the areas with the highest and the lowest consumption rates (Avilés, 19 DID; Oviedo, 11.5 DID). A high variability between health areas was observed when analysing data temporally (difference of 11.8 DID in 2011) and therapeutic groups. The consumption of macrolides in Langreo health area and quinolones in Jarrio health area were 2.3 and 4.1 times higher, respectively, comparing to Gijón health area.
Conclusions. There is a wide quantitative and qualitative variability of antibiotic consumption in the pediatric outpatients among the different health areas of Asturias.

Rev Esp Quimioter 2021; 34(2): 107-114 [Texto completo PDF]


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Rev Esp Quimioter 2021; 34(2): 151-153

Dalbavancina como tratamiento antibiótico supresor. A propósito de 1 caso

JOSÉ MARÍA BARBERO ALLENDE, MARTA GARCÍA SÁNCHEZ, ANA MARÍA CULEBRAS LÓPEZ, ROSA AGUDO ALONSO

Published: 25 Janurary 2021

http://www.doi.org/10.37201/req/105.2020

LETTER TO THE EDITOR

Rev Esp Quimioter 2021; 34(2): 151-153 [Texto completo PDF]


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Rev Esp Quimioter 2021; 34(2): 100-106

Evolution of antimicrobial resistance and mortality in Staphylococcus aureus endocarditis during 15 years in a university hospital

MARCOS RODRÍGUEZ ESTEBAN, JESÚS ODE FEBLES, SARA ISABEL MIRANDA MONTERO, MARÍA RAMOS LÓPEZ, MARCOS FARRAIS VILLALBA, LUIS ÁLVAREZ ACOSTA, ALEJANDRO QUIJADA FUMERO, JULIO HERNÁNDEZ AFONSO, ANTONIO CABRERA LEÓN

Published: 25 January 2021

http://www.doi.org/10.37201/req/103.2020

Introduction. One of the most aggressive microorganisms in infective endocarditis (IE) is Staphylococcus aureus. We analyse the resistance of S. aureus to antibiotics and its impact on the clinical course of IE in a recent 15-year period.
Methods. Retrospective study of patients with IE in a university hospital from 2005 to 2019. Bivariate and multivariate analysis of severity at admission, comorbidities, minimum inhibitory concentrations (MIC) and mortality.
Results. Of the 293 IE cases, 66 (22.5%) were due to S. aureus, and 21 (7.2%) were methicillin-resistant S. aureus (MRSA). The prevalence of strains with a MIC to vancomycin ≥ 1mg/L increased from 4.8% to 63.6% (p <0.001) and the cases of MRSA from 38 to 27.3% (p = 0.045). Older age (p= 0.02), comorbidity (p <0.01) and nosohusial origin (p = 0.01), were factors associated with MRSA. But the antimicrobial resistance and severity on admission were not associated with exitus; predictive factors were the right-sided IE (OR = 0.08; 95% CI: 0.01-0.51), comorbidities (OR per Charlson index point = 1.30; 95% CI: 1.01-1.69) and creatinine on admission (OR per mg / dL = 1.56; 95% CI = 1.01- 2.35; p = 0.04).
Conclusion. We have experienced an increase in IE cases with MIC to vancomycin ≥ 1mg/L, without significant variation in infections due to MRSA. Antimicrobial resistance was not associated with mortality, but comorbidity and left involvement were predictive factors.

Rev Esp Quimioter 2021; 34(2): 100-106 [Texto completo PDF]


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Rev Esp Quimioter 2021; 34(1): 64-66

Tuberculosis cases presenting with spontaneous hemopneumothorax and hypotension

AYSEGUL BAYSAK, DENIZ AKPINAR, KENAN CAN CEYLAN, GULFEM ECE, ELIF DUMAN, ADNAN TOLGA OZ, CEM ECE

Published: 2 Janurary 2021

http://www.doi.org/10.37201/req/070.2020

LETTER TO THE EDITOR

Rev Esp Quimioter 2021; 34(1): 64-66 [Full-text PDF]


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