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Rev Esp Quimioter 2022; June 21

Expert opinion on strategies to improve vaccination coverage against seasonal influenza

CARMEN VELICIA PEÑAS, VÍCTOR MIGUEL DEL CAMPO PÉREZ, IRENE RIVERO CALLE, LORENZO ARMENTEROS DEL OLMO, MARÍA TERESA PÉREZ RODRÍGUEZ, JUAN JESÚS GESTAL OTERO

Published: 21 June 2022

http://www.doi.org/10.37201/req/031.2022

Seasonal flu continues to be a major public health concern, and the influenza vaccine remains the most effective preventive measure. In Spain, vaccination coverage data from previous seasons show vaccination rates well below official targets; however, these figures improved significantly after the COVID-19 pandemic. Given the importance of achieving and maintaining high vaccination rates in order to avoid the clinical and economic impact of influenza, our multidisciplinary group of experts on vaccines analyzed the impact of low vaccination rates in Spain and drafted a series of measures to boost influenza vaccination coverage, particularly among priority groups.

Rev Esp Quimioter 2022; June  21 [Texto completo PDF]


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Rev Esp Quimioter 2022; June 20

Comparison between five PCR techniques for the diagnosis of SARS-CoV-2

ALBERTO TENORIO-ABREU, ANA RUIZ-CASTILLO, ANTONIO FRANCISCO GUZMÁN-GONZÁLEZ, ALEJANDRO PEÑA-MONJE, JOSÉ MARÍA SAAVEDRA-MARTÍN, FRANCISCO FRANCO-ÁLVAREZ DE LUNAO

Published: 20 June 2022

http://www.doi.org/10.37201/req/076.2020

Introduction. Since the first cases of SARS-CoV-2 appeared, there have been numerous techniques that have been developed for the diagnosis or monitoring of infection, both direct and serological techniques. Choosing a good diagnostic tool is essential for epidemiological control. The objective was to compare five commercialized RT-PCR techniques in real time, in sensitivity, specificity and agreement for the detection of SARS-CoV-2.
Material and methods. Five commercial RT-PCR kits for the detection of SARS-CoV-2 were compared. Eight known positive samples were taken and subjected to seven different dilutions or concentrations, and another 135 negative samples were used to determine sensitivity, specificity, and agreement values.
Results. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the Palex, Roche and GeneXpert techniques with respect to Seegene were identical, corresponding to 98.21%, 100%, 100% and 99.26% respectively. For Becton Dickinson the sensitivity was 89.28%, the specificity of 100%, the PPV of 100% and the NPV of 95.74%. The agreement using the Kappa index for Palex, Roche and GeneXpert was 0.9892, while the agreement for Becton Dickinson was with a Kappa index of 0.9215.
Conclusion. All commercial RT-PCR kits had high sensitivities and specificities, as well as PPV, NPV, and concordance.

Rev Esp Quimioter 2022; June  20 [Texto completo PDF]


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Rev Esp Quimioter 2022; June 17

Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient  

DAVID SÁNCHEZ-RAMOS, ESTEBAN VEGA-TORRES, CARLOS IRLES-VIDAL, JAVIER COLOMINA-RODRÍGUEZ

Published: 17 June 2022

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/034.2022

Rev Esp Quimioter 2022; June 17  [Full-text PDF]


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Rev Esp Quimioter 2022; June 9

Impact of one year of pandemic on Spanish Intensive Care Units

PABLO VIDAL-CORTÉS, MARÍA CRUZ MARTÍN, EMILI DÍAZ, MARÍA BODÍ, JOSÉ CARLOS IGEÑO, JOSÉ GARNACHO-MONTERO

Published: 9 June 2022

http://www.doi.org/10.37201/req/025.2022

Objective. To measure the impact of the pandemic in Spanish ICUs.
Material and methods. On-line survey, conducted in April 2021, among SEMICYUC members. Participants were asked about number of patients admitted, increase in the number of beds and staff, structures created in the hospital and self-assessment of the work performed.
Results. We received 246 answers from 157 hospitals. 67.7% of the ICUs were expanded during the pandemic, overall increase in beds of 58.6%. The ICU medical staff increased by 6.1% and there has been a nursing shortage in 93.7% of units. Patients exceeded 200% the pre-pandemic ICU capacity. In 88% of the hospitals the collaboration of other specialists was necessary. The predominant collaboration model consisted of the intensive care medicine specialist being responsible for triage and coordinating patient management. Despite that 53.2% centres offered training for critical care, a deterioration in the quality of care was perceived. 84.2% hospitals drew up a Contingency Plan and in 77.8% of the hospitals a multidisciplinary committee was set up to agree on decision-making. Self-evaluation of the work performed was outstanding and 91.9% felt proud of what they had achieved, however, up to 15% considered leaving their job.
Conclusions. The Spanish ICUs assumed an unprecedented increase in the number of patients. They achieved it without hardly increasing their staff and, while intensive care medicine training was carried out for other specialists who collaborated. The degree of job satisfaction was consistent with pre-pandemic levels.
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Rev Esp Quimioter 2022; June 9 [Full-text PDF]


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Rev Esp Quimioter 2022; June 9

Síndrome de absceso hepático asociado a colecistitis por Klebsiella pneumoniae hipervirulenta K1 ST23  

DOMINGO FERNÁNDEZ VECILLA, CRISTINA ASPICHUETA VIVANCO, FELICITAS ELENA CALVO MURO, LANDER ANTÓN MÉNDEZ, JOSÉ LUIS DÍAZ DE TUESTA DEL ARCO

Published: 9 June 2022

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/024.2022

Rev Esp Quimioter 2022; June 24  [Texto completo PDF]


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Rev Esp Quimioter 2022; June 6

Sociodemographic characteristics and risk factors associated to significative bacteriuria in a Spanish health area

Mª DEL MAR RODRÍGUEZ DEL ÁGUILA, ANTONIO SORLÓZANO-PUERTO, Mª AMELIA FERNÁNDEZ-SIERRA, JOSÉ Mª NAVARRO MARÍ, JOSÉ GUTIÉRREZ FERNÁNDEZ

Published: 6 June 2022

http://www.doi.org/10.37201/req/016.2022

Objective. To determine the epidemiological characteristics of significative bacteriuria (SB) and their relationship with sociodemographic factors and to analyze risk factors in inpatients.
Material and methods. Cross-sectional descriptive study carried out on urine culture samples received between 2016-2020 in the Microbiology laboratory, differentiating between minors and adults. The dependent variable was the presence of SB and the independent variables were age, sex, year, type of sample and source of the sample. In urine cultures of inpatients, risk factors were evaluated from the Minimum Basic Data Set.
Results. A total of 68,587 valid records (96.3% of the total) were analyzed. 40.8% (95% CI: 40.4%-41.2%) of urine cultures in adults and 33.8% (95% CI: 32.9%-34.7%) in children were positive, with an incidence that ranged in adults between 18.2 cases/1,000 inhabitants in 2016 and 14.6 cases/1,000 inhabitants in 2020 and 21.1 and 8.4 cases/1,000 inhabitants respectively in minors. Positive urine cultures were more frequent in children from urban areas compared to rural areas (OR=1.37; p<0.01). In hospitalized adults, for each year of age the risk of SB increased by 2%, it was 36% higher in women, 18% higher in obese patients and 17% more frequent in patients with kidney disease, (p<0.01). No relationship was observed between SB and diagnosis of COVID-19.
Conclusion. The sociodemographic characteristics of the population with SB in our health area are similar to those found in other geographical areas worldwide, observing a decreasing trend in incidence in the years studied. The frequency of SB in children is higher in urban areas.

Rev Esp Quimioter 2022; June 6 [Texto completo PDF]


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Rev Esp Quimioter 2022; June 2

Efficacy and safety of outpatient parenteral antibiotic therapy in patients with infective endocarditis: a meta-analysis

WEN WEN, HONG LI, CHUNYI WANG, CHEN CHEN, JIAKE TANG, MENGYUN ZHOU, XUWEI HONG, YONGRAN CHENG, QI WU, XINGWEI ZHANG, ZHANHUI FENG, MINGWEI WANG

Published: 2 June 2022

http://www.doi.org/10.37201/req/011.2022

Background. To investigate the clinical outcome of patients with infective endocarditis (IE) during and after outpatient parenteral antimicrobial treatment (OPAT), and to further clarify the safety and efficacy of OPAT for IE patients.
Methods. Through December 20, 2021, a total of 331 articles were preliminarily searched in Pubmed, Web of Science, Cochrane Library and Embase, and 9 articles were eventually included in this study.
Results. A total of 9 articles comprising 1,116 patients were included in this study. The overall mortality rate of patients treated with OPAT was 0.04 (95% CI, 0.02-0.07), that means 4 deaths per 100 patients treated with OPAT. Separately, mortality was low during the follow-up period after OPAT treatment, with an effect size (ES) of 0.03 (95%CI, 0.02-0.07) and the mortality of patients during OPAT treatment was 0.04 (95% CI, 0.01-0.12). In addition, the readmission rate was found to be 0.14 (95% CI, 0.09-0.22) during the follow-up and 0.18 (95% CI, 0.08-0.39) during treatment, and 0.16 (95% CI, 0.10-0.24) for patients treated with OPAT in general. Regarding the relapse of IE in patients, our results showed a low overall relapse rate, with an ES of 0.03 (95% CI, 0.01-0.05). In addition, we found that the incidence of adverse events was low, with an ES of 0.26 (95% CI, 0.19-0.33).
Conclusion. In general, the incidence of adverse events and mortality, readmission, and relapse rates in IE patients treated with OPAT are low both during treatment and follow-up period after discharge, indicating that OPAT is safe and effective for IE patients. However, our study did not compare routine hospitalization as a control group, so conclusions should be drawn with caution. In order to obtain more scientific and rigorous conclusions and reduce clinical risks, it is still necessary to conduct more research in this field and improve the patient selection criteria for OPAT treatment, especially for IE patients. Finally, clinical monitoring and follow-up of OPAT-treated patients should be strengthened.

Rev Esp Quimioter 2022; June 2 [Full-text PDF]


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Rev Esp Quimioter 2022; May 31

The importance of an early gastroenteritis diagnosis to discard MIS-C during SARS-CoV-2 pandemic  

MARÍA FERNÁNDEZ MIAJA, ANA VIVANCO ALLENDE, SARA DELGADO-NICOLÁS, MA EUGENIA LLANEZA-VELASCO, JAVIER FERNÁNDEZ DOMÍNGUEZ

Published: 31 May 2022

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/170.2021

Rev Esp Quimioter 2022; May 31  [Full-text PDF]


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Rev Esp Quimioter 2022; May 30

Erratic enteric absorption of dolutegravir in a critically ill patient  

MARTA DE ANTONIO-CUSCÓ, FRANCISCO JOSÉ PARRILLA, HERNANDO KNOBEL FREUD, DANIEL ECHEVERRÍA-ESNAL, ANDREA CASTELLVÍ FONT, ANTONIA VÁZQUEZ, JOAN RAMON MASCLANS, OLIVIA FERRÁNDEZ, SANTIAGO GRAU

Published: 30 May 2022

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/004.2022

Rev Esp Quimioter 2022; May 30  [Full-text PDF]


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Rev Esp Quimioter 2022; May 24

Real-world efficacy of switching to bictegravir/ emtricitabine/tenofovir alafenamide in pretreated patients with triple therapy containing rilpivirine

ALEJANDRO DE GEA GRELA, LUZ MARTÍN CARBONERO, RAFAEL MICÁN, JOSÉ IGNACIO BERNARDINO, LUIS RAMOS, Mª EULALIA VALENCIA

Published: 24 May 2022

http://www.doi.org/10.37201/req/013.2022

Objective. To analyze the efficacy and tolerability of the strategy to change from rilpivirine (RPV) based regimens to bictegravir / emtricitabine / tenofovir alafenamide (B/F/TAF).
Methods. Single-center, observational and retrospective study. Patients who made the change to B/F/TAF before February 2020 were selected, analyzing the results after 24 and 48 weeks. The percentage that remained with an undetectable viral load was determined, as well as the changes in CD4 + lymphocytes, metabolic parameters and renal function.
Results. A total of 42 patients were included. Thirty-two of the 35 patients (91.4%) who completed the 48 weeks of follow-up had an undetectable viral load. The CD4 + lymphocyte count remained stable at 24 and 48 weeks. The response to B/F/TAF was not influenced by the two analogs previously received.
Conclusion. Switching from triple therapy with RPV to B/F/TAF is a safe and effective strategy in real life.

Rev Esp Quimioter 2022; May 24 [Texto completo PDF]