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Rev Esp Quimioter 2023; 36(3): 267-274

Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study

MARTA ENCABO, ELENA HERNÁNDEZ-ÁLVAREZ, DAVID OTEO, ANA GARCÍA-ÁLVAREZ, MERCEDES MARTÍNEZ-NOVILLO GONZÁLEZ, MARÍA TERESA SANZ-CASLA, JUAN GONZÁLEZ-DEL CASTILLO

Published: 20 March 2023

http://www.doi.org/10.37201/req/108.2022

Background. The aim of the present study was to evaluate the diagnostic performance of monocyte distribution width (MDW) as a biomarker for sepsis diagnosis in severe patients attended in the Emergency Department for different conditions and not only infections.
Methods. We performed an observational study in a consecutive prospective cohort including severe patients attending the Emergency Department with different conditions. MDW and other biomarkers were determined from samples obtained during the first care of patients. The diagnostic performance of the different biomarkers was determined based on the final diagnosis at patient discharge.
Results. One hundred two patients, with a mean age of 76.7 (SD 16.5) years were included, 53 being (51.9%) male. Among the patients included, 65 (63.7%) had an infectious disease while the remaining had other different conditions. A MDW cut-off of 20.115 provided the best accuracy to identify infected patients, with a sensitivity of 89.2 (95% CI 79.4-94.7), a specificity of 89.2 (95% CI 75.3-95.7), a positive predictive value of 93.5 (95% CI 84.6-97.5), a negative predictive value of 82.5% (95% CI 68.0-91.3), a positive likelihood ratio of 8.25 (3.26-20.91), and a negative likelihood ratio of 0.12 (0.06-0.24). The area under the receiver operating characteristic curve for infection according to MDW was 0.943 (95% CI 0.897-0.989; p<0.001).
Conclusions. A MDW > 20.115 may be associated with infection and could help to distinguish between infected and non-infected patients in severe patients. These results must be confirmed in new studies due to the limited patient sample included.

Rev Esp Quimioter 2023; 36(3): 267-274 [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 325-328

Periprosthetic joint infection caused by Haemophilus parainfluenzae. Case report and literature review  

MARINA MEDEL-PLAZA, ÁLVARO AUÑÓN, ANTONIO BLANCO, JOAQUÍN GARCÍA-CAÑETE, LLANOS SALAR-VIDAL, JAIME ESTEBAN

Published: 16 March 2023

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/127.2022

Rev Esp Quimioter 2023; 36(3): 325-328 [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 310-313

Epidemiology and prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium in a tertiary hospital from Madrid, Spain

ALFREDO MALDONADO-BARRUECO, MONSERRAT RODRÍGUEZ-AYALA, DAVID GRANDIOSO-VAS, PALOMA GARCÍA-CLEMENTE, GLADYS VIRGINIA GUEDEZ-LÓPEZ, JULIO GARCÍA-RODRÍGUEZ, INMACULADA QUILES-MELERO

Published: 10 March 2023

http://www.doi.org/10.37201/req/123.2022

Objectives. Mycoplasma genitalium causes persistent sexually transmitted infections. The aims of this study were to estimate the prevalence of resistances to macrolides and fluoroquinolones in M. genitalium and the sexually transmitted coinfections in patients at Hospital Universitario La Paz (Madrid, Spain).
Material and methods. Patients attended between January and October 2021 were studied. Screening for sexually transmitted pathogens and detection of 23S rRNA and parC genes mutations were performed by real-time PCR (Allplex,SeegeneTM).
Results. A total of 1,518 females and 1,136 males were studied. The prevalence of M. genitalium was 2.1%. The macrolides resistance rate was 51.8%. The mutations found were A2059G, A2058T and A2058G. The rate of resistance to fluoroquinolones was 17.8% being the G248T mutation (S83I) the most frequent. Seven males had some sexual transmitted coinfection.
Conclusions. Although the percentage of M. genitalium infections is low, the high rate of resistance to macrolides makes it necessary to revise the protocols for diagnosis and empirical treatment of sexually transmitted infections. The use of fluoroquinolones is appropriate after screening of macrolide resistance profile.

Rev Esp Quimioter 2023; 36(3): 310-313 [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 319-321

Identification of Anaerobiospirillum succiniciproducens by MALDI-TOF mass spectrometer. A bacteremia in an immunocompetent patient  

DOMINGO FERNÁNDEZ VECILLA, MIKEL JOSEBA URRUTIKOETXEA GUTIÉRREZ, MATXALEN VIDAL GARCÍA, JOSU MIRENA BARAIA-ETXABURU ARTETXE

Published: 8 March 2023

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/109.2022

Rev Esp Quimioter 2023; 36(3): 319-321  [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 275-281

Antibiotic resistance changes in episodes of symptomatic bacteriospermia: development in a health area of southeast Spain

RAÚL MENDOZA-RODRÍGUEZ, ITAHISA HERNÁNDEZ-CHICO, MANUELA EXPÓSITO-RUIZ, JOSÉ MARÍA NAVARRO-MARÍ, JOSÉ GUTIÉRREZ-FERNÁNDEZ, ANTONIO ROSALES-CASTILLO

Published: 4 March 2023

http://www.doi.org/10.37201/req/117.2022

Background. Chronic bacterial prostatitis (CBP) is an entity of difficult clinical diagnosis and treatment, being the microbiological study of semen the main diagnostic test. This study aimed to determine the etiology and antibiotic resistance in patients with symptomatic bacteriospermia (SBP) in our environment.
Material and methods. A cross-sectional and retrospective descriptive study has been carried out from a Regional Hospital of the Spanish Southeast. The participants were patients assisted in the consultations of the Hospital with clinic compatible with CBP, between 2016 and 2021. The interventions were collection and analysis of the results derived from the microbiological study of the semen sample. The main determinations were the etiology and rate of antibiotic resistance of BPS episodes are analyzed.
Results. The main isolated microorganism is Enterococcus faecalis (34.89%), followed by Ureaplasma spp. (13.74%) and Escherichia coli (10.98%). The rate of antibiotic resistance of E. faecalis to quinolones (11%) is lower than previous studies, while for E. coli it has been higher (35%). The low rate of resistance shown by E. faecalis and E. coli to fosfomycin and nitrofurantoin stands out.
Conclusions. In the SBP, gram-positive and atypical bacteria are established as the main causative agents of this entity. This forces us to rethink the therapeutic strategy used, which will avoid the increase in antibiotic resistance, recurrences, and chronicity of this pathology.

Rev Esp Quimioter 2023; 36(3): 275-281 [Texto completo PDF]


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Rev Esp Quimioter 2023; 36(3): 322-324

Response to “The importance of an early gastroenteritis diagnosis to discard MIS-C during SARS-CoV-2 pandemic”  

PATRICIA RODRÍGUEZ-LORENZO, MARTA ARIAS-TEMPRANO, ALEJANDRA MÉNDEZ-SÁNCHEZ, CARLOS PÉREZ-MÉNDEZ

Published: 3 March 2023

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/120.2022

Rev Esp Quimioter 2023; 36(3): 322-324  [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 317-318

Primer brote de Clostridioides difficile ribotipo 027 en Canarias  

MARÍA AROCA-FERRI, TOMÁS TOSCO-NÚÑEZ, MÓNICA PEÑATE-BOLAÑOS, JESÚS MOLINA-CABRILLANA, MAR OJEDA-VARGAS

Published: 2 March 2023

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/105.2022

Rev Esp Quimioter 2023; 36(3): 317-318  [Texto completo – PDF]


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Rev Esp Quimioter 2023; 36(2):125-143

Impact of the COVID-19 pandemic on the mental health of the general population and health care workers

EMILIO BOUZA, CELSO ARANGO, CARMEN MORENO, DIEGO GRACIA, MANUEL MARTÍN, VÍCTOR PÉREZ, LUISA LÁZARO, FRANCISCO FERRE, GONZALO SALAZAR, FRANCISCO TEJERINA-PICADO, MERCEDES NAVÍO, JAVIER GRANDA REVILLA, ESTEBAN PALOMO, PEDRO R. GIL-MONTE

Published: 21 February 2023

http://www.doi.org/10.37201/req/018.2023

The Health Sciences Foundation has assembled a multidisciplinary group around a series of questions about the impact of the COVID-19 pandemic on the mental health of the general population and specific groups within that population, particularly healthcare workers.
In the general population, the most prevalent mental disorders have been anxiety, sleep disorders and affective disorders, primarily depression. There has been a considerable increase in suicidal behavior, especially in young women and men over 70 years of age. There has been an increase in alcohol abuse and nicotine, cannabis and cocaine use. In contrast, the use of synthetic stimulants during periods of confinement has decreased. With regard to non-substance addictions, gambling was very limited, pornography consumption increased significantly and there was an increase in compulsive shopping and the use of video games.
Particularly vulnerable groups include adolescents and patients with autism spectrum disorders. Healthcare workers suffered an increase in depression, anxiety and post-traumatic stress, especially those who were exposed during the early stages of the pandemic. Female sex, being a nurse, proximity to patients with COVID-19, working in a rural environment and having previous psychiatric or organic illnesses were some of the most frequently repeated factors in various studies in this population group.
The media have shown a good degree of knowledge about these problems and have dealt with them frequently and from the point of view of ethics, crisis situations, such as the one experienced, have triggered not only physical but also moral claudications.

Rev Esp Quimioter 2023; 36(2):125-143 [Full-text PDF]


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Rev Esp Quimioter 2023; 36(2):220-222

Soft-tissue infection due to Mycoplasma hominis 

ANA RUIZ CASTILLO, ENRIQUE LÓPEZ HERRERO, ALBERTO TENORIO ABREU, ÁGATA GONZÁLEZ GÓMEZ-LOZANO, JOSÉ MARÍA SAAVEDRA MARTÍN

Published: 20 February 2023

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/115.2022

Rev Esp Quimioter 2023; 36(2):220-222  [Full-text PDF]


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Rev Esp Quimioter 2023; 36(3): 223-235

Status of Herpes Zoster and Herpes Zoster Vaccines in 2023: A position paper

JOSÉ MARÍA MOLERO GARCÍA, SANTIAGO MORENO GUILLÉN, FERNANDO RODRÍGUEZ-ARTALEJO, JULIÁN RUIZ-GALIANA, RAFAEL CANTÓN, PILAR DE LUCAS RAMOS, ALEJANDRA GARCÍA-BOTELLA, ALBERTO GARCÍA-LLEDÓ, TERESA HERNÁNDEZ-SAMPELAYO, JAVIER GÓMEZ-PAVÓN, JUAN GONZÁLEZ DEL CASTILLO, MARI CRUZ MARTÍN-DELGADO, FRANCISCO JAVIER MARTÍN-SÁNCHEZ, MANUEL MARTÍNEZ-SELLÉS EMILIO BOUZA

Published: 8 February 2023

http://www.doi.org/10.37201/req/004.2023

Herpes zoster infection (HZ) is an important public health problem due to its high incidence and frequent complications, especially post-herpetic neuropathy . The incidence of HZ increases with age and is more frequent in immunocompromised patients. It is estimated that at least 60,000 people develop HZ each year in Spain.
The usual forms of HZ are so clinically characteristic that they do not usually require microbiological confirmation, which is reserved for cases without cutaneous manifestations or with atypical presentation.
There are currently two vaccines approved by the regulatory agencies and marketed in Spain to prevent the onset of HZ and its complications. The first (Zostavax®) was marketed by the company MSD and licensed in Europe in 2006 and is a live attenuated virus vaccine that is administered in a single dose, while the second (Shingrix®) is a recombinant vaccine, marketed in 2017 and requires two doses. While the former cannot be administered to immunocompromised persons, the latter can be prescribed to any group of adults.
The criteria for the indication and financing of these vaccines have not been uniform in the various autonomous communities of Spain.
These and other aspects of HZ have been discussed by a group of experts from the Illustrious Official College of Physicians of Madrid (ICOMEM) whose criteria and opinions are included in this paper.

Rev Esp Quimioter 2023; 36(3): 223-235 [Full-text PDF]


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