Rev Esp Quimioter 2017; 30(6): 397-406

Update on management of invasive candidiasis

FRANCISCO JAVIER CANDEL, CARMEN PAZOS PACHECO, ISABEL RUIZ-CAMPS, EMILIO MASEDA, MARIA DEL ROSARIO SÁNCHEZ-BENITO, ANA MONTERO, MIREIA PUIG, FERNANDO GILSANZ, JUAN AGUILAR, MAYRA MATESANZ

Given the growing incidence of invasive candidiasis in critically ill and haemato-oncological patients and its poor outcomes, an early diagnosis and treatment are need for get a better prognosis. This document reviews the current approaches that help in diagnosis of invasive candidiasis based on culture-independent microbiological tests. The combination of clinical prediction scores with fungal serological markers could facilitate the approach in antifungal therapy, optimizing it. This article also reviews the epidemiology and primary risk factors for invasive candidiasis in these patients, updating the therapeutic approach algorithms in both clinical contexts based on the main evidence and international guidelines.

Rev Esp Quimioter 2017; 30(6): 397-406 [Full-text PDF]