Rev Esp Quimioter 2018; 31(2): 118-122

Prophylactic antibiotherapy in hip arthroplasty. Cohort study

MARÍA GARROTE-GARROTE, JUAN ANTONIO DEL-MORAL-LUQUE, ANTONIO CHECA-GARCÍA, JOSÉ FRANCISCO VALVERDE-CÁNOVAS, CAROLINA CAMPELO-GUTIÉRREZ, JAVIER MARTÍNEZ-MARTÍN, ÁNGEL GIL-DE-MIGUEL, GIL RODRÍGUEZ-CARAVACA

Introduction. The surgical site infection is the main cause of nosocomial infection in surgical patients, being antibiotic prophylaxis one of the most important factors for preventing it. This study evaluates adequacy of antibiotic prophylaxis in hip arthroplasty surgery as well as its effect on preventing surgical site infection.
Material and methods. A prospective cohort study was carried out from January 2011 to December 2016. We assessed the degree of adequacy of antibiotic prophylaxis in hip arthroplasty. Incidence of surgical site infection was studied after a maximum incubation period of 90 days. In order to assess the effect of inadequate prophylaxis on surgical site infection we used the relative risk adjusted with a logistic regression model.
Results. We studied 681 patients. Incidence of surgical site infection was 4% (95% CI 2.5-5.5). Antibiotic prophylaxis was administered in 99% of cases, with an overall protocol adequacy of 74%. The main cause of non-compliance was the length of prescription (22.2%; 149 patients). The effect of inadequate prophylaxis on surgical site infection was RRadjusted=0.47; 95%CI 0.19-1.17, (p>0.05).
Conclusions. Adequacy of antibiotic prophylaxis was high. No relationship between prophylaxis adequacy and incidence of surgical site infection was founded. Surveillance allows us to assess surgical site infection and risk factors.

Rev Esp Quimioter 2018; 31(2): 118-122 [Texto completo PDF]