Rev Esp Quimioter 2022;35(Suppl.1):31-34

Cefiderocol

MARÍA CRUZ SORIANO, JESSIE MONTUFAR, AARON BLANDINO-ORTIZ

Published: 22 April 2022

http://www.doi.org/10.37201/req/s01.07.2022

Cefiderocol is a new siderophore cephalosporin with potent in vitro activity against gram-negative bacilli including Enterobacterales that produce all kinds of carbapenemases and non-fermenting Gram-negative with difficult-to-treat resistance. As a β-lactam, its efficacy is optimized in extended-perfusion and requires dose adjustment in renal dysfunction and hyperclearance. Its efficacy has been validated in three clinical trials, one of them in the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia. The clinical trial aimed at difficult-to-treat gram-negatives achieved the clinical and microbiological target, but the increase in mortality observed in the cefiderocol arm makes it necessary to demonstrate efficacy in real clinical practice. Cefiderocol is a good option among the new β-lactams for the treatment of pneumonia caused by Gram-negative bacilli carbapenem-resistant.

Rev Esp Quimioter 2022; 35(Suppl. 1):31-34 [Full-text PDF]