Rev Esp Quimioter 2024; 37(6): 486-497
Diagnostic power of LIAISON MeMed VB® for bacterial infection in adults patients seen in Emergency Departments due to infections
JAVIER CABAÑAS MORAFRAILE, ELENA DE RAFAEL GONZÁLEZ, LAURA SERRANO MARTÍN, RAFAEL RUBIO DÍAZ, MARÍA TORRES FERNÁNDEZ, EVA HEREDERO GÁLVEZ, WILLIAM ESNEIDER LÓPEZ FORERO, LAURA MORELL JURADO, RAÚL CANABAL BERLANGA, M. FRANCISCA CALAFELL MAS, ELIA CHAVES PRIETO, M. REMEDIOS ASENSIO NIETO, ÁLVARO THOMAS-BALAGUER CORDERO, MARÍA CARMEN LORENZO LOZANO, AGUSTÍN JULIÁN-JIMÉNEZ, EN NOMBRE DEL GRUPO URGEN-LABQMIC DEL CHUT (IDISCAM)
Published: 16 October 2024
http://www.doi.org/10.37201/req/078.2024
Objectives. To analyze the diagnostic accuracy of the new MeMed® test to predict bacterial infection in adult patients seen in emergency departments (ED) with clinical suspicion of infection, as well as to compare its performance with other commonly used biomarkers (protein C reactive-PCR-, procalcitonin -PCT-).
Methods. A prospective, observational and analytical study was carried out on adult patients who were treated in an ED with the clinical diagnosis of an infectious process. Follow-up was carried out for 30 days. The diagnosis of bacterial infection (BI) was considered as the dependent variable. The predictive ability was analyzed with the area under the curve (AUC) of the receiver operating characteristic (COR) and the values of sensitivity (Se), specificity (Es), positive predictive value (PPV) and negative predictive value (NPV) of the PCR, PCT, leukocyte count and the LIAISON® MeMed® test.
Results. The study included 258 patients, 54 (15.6%) of whom died within 30 days of visiting the ED. The mean age was 68.28 (SD 19.53) years, 57.4% (148) were men. At 30 days, the group with the IB diagnosis had 137 patients, the viral infection group 68 cases and 17 in the indeterminate group. The AUC-COR achieved by MeMed® in the group that analyzes all patients was 0.920 (95% CI: 0.877-0.962) and the PCT was 0.811 (95% CI: 0.754-0.867). With a cut-off point (PC) > 65 points of the MeMed® test, achieves a Se: 79.2% and Es: 91.2% and with PC > 90 points a Se: 57% and Es: 95.9%. Applying the Youden index, the PC > 50 points achieves Se:84.1% and Es:88.2%.
Conclusions. In adult patients treated with clinical suspicion of infection in the ED, the LIAISON MeMed® test has a great ability to diagnose its bacterial origin and achieves better performance than PCT, PCR and leukocyte count.
Rev Esp Quimioter 2024; 37(6): 486-497 [Texto completo PDF]
