CRISTINA CARRANZA-RODRÍGUEZ, TOMÁS TOSCO-NUÑEZ, NIEVES JAÉN-SÁNCHEZ, LAURA SUÁREZ-HORMIGA, JOSÉ-LUIS PÉREZ-ARELLANO
Published: 12 July 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/047.2024
Rev Esp Quimioter 2024; 37(5): 435-437 [Full-text PDF]
Mª LUISA MONFORTE, ROCÍO CEBOLLADA, Mª JESÚS ESCOBAR, RAQUEL ABAD, CARMEN ASPIROZ
Published: 10 July 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/040.2024
Rev Esp Quimioter 2024; 37(5): 427-428 [Texto completo PDF]
RAFAEL CANTÓN, PILAR DE LUCAS RAMOS, ALEJANDRA GARCÍA-BOTELLA, ALBERTO GARCÍA-LLEDÓ, TERESA HERNÁNDEZ-SAMPELAYO, JAVIER GÓMEZ-PAVÓN, JUAN GONZÁLEZ DEL CASTILLO, MARI CRUZ MARTÍN-DELGADO, FRANCISCO JAVIER MARTÍN SÁNCHEZ, MANUEL MARTÍNEZ-SELLÉS, JOSÉ MARÍA MOLERO GARCÍA, SANTIAGO MORENO GUILLÉN, FERNANDO RODRÍGUEZ-ARTALEJO, ELENA REIGADAS, ROSA DEL CAMPO, SERGIO SERRANO, JULIÁN RUIZ-GALIANA, EMILIO BOUZA
Published: 9 July 2023
http://www.doi.org/10.37201/req/056.2024
The study of the microbiota and the microbiome, and specifically the intestinal one, has determined great interest due to the possible association of their alterations with numerous diseases. These include entities as diverse as Crohn’s disease, autism, diabetes, cancer or situations as prevalent today as obesity. In view of this situation, different recommendations have been performed regarding the use of probiotics, prebiotics, and postbiotics as modulators of the microbiota and the microbiome, seeking both preventive and therapeutic effects, and faecal material transfer (FMT) is proposed as an alternative. The latter has emerged as the only proven beneficial intervention on the intestinal microbiome, specifically in the treatment of recurrent colitis associated with Clostridioides difficile (R-CDI). In the rest of the entities, the lowering of laboratory costs has favored the study of the microbiome, which is resolved by delivering reports with catalogs of microorganisms, metabolites or supposed biomarkers without consensus on their composition associated with healthy or diseased microbiota and the disease. There is still insufficient evidence in any disease for interventions on the microbiome beyond FMT and R-CDI. Multi- and multi-disciplinary work with extensive research and the application of artificial intelligence in this field may shed light on the questions raised currently. Ethical issues must also be resolved in light of possible interventions within the umbrella of personalized medicine.
Rev Esp Quimioter 2024; 37(6): 438-453 [Full-text PDF]
ANA DE MALET PINTOS-FONSECA, SUSANA OROL MASEDA, ISABEL LOPEZ LOPEZ, REBECA RODIL FERREIRO, CARLOS RUIZ DE ALEGRÍA PUIG, PILAR ALONSO GARCIA
Published: 8 July 2023
http://www.doi.org/10.37201/req/038.2024
Introduction. The Autonomous Community of Galicia has adopted DECREE 216/2011 on health standards for poultry production, in addition to the Spanish national programs. However, no program has yet been implemented to eradicate campylobacteriosis, which shares the same reservoir. The aim of this study was to compare the evolution of Salmonella spp. isolates with respect to those of Campylobacter spp. in faecal samples received by the Microbiology Department.
Material and methods. A retrospective descriptive comparative study was conducted through the Laboratory Information System (SIL) of Salmonella spp. isolated against Campylobacter spp. in faeces between 2011 and 2022 at the Lucus Augusti University Hospital (HULA), Lugo, Spain.
Results. A total of 35,704 stool samples were analysed, of which 3,045 were positive. 751 Salmonella spp. were isolated. Statistical differences were observed in the annual distribution (p<0.01), with a clear turning point in 2018. Five hundred and five patients required hospital care, especially in 2014 with 72 patients (69%). On the other hand, 1,587 Campylobacter spp. were isolated. Required hospital care 1,002 patients during the study, with a peak in 2019 with 111 cases (62%).
Conclusion. The reduction of salmonellosis cases and the maintenance of campylobacteriosis cases are directly related to the implementation of DECREE 216/2011. This, in turn, has reduced the pressure on hospitals in the HULA health area. Therefore, we believe that the ONE Health concept is being strengthened in the area studied.
Rev Esp Quimioter 2024; 37(5): 409-414 [Full-text PDF]
PATRICIO FAVIER, LORENA ABUSAMRA, SANTIAGO MONCALERO, LAURA ERRECALDE, SILVIA MONTIBELLO, OLGA RODRÍGUEZ, SANDRA COGUT, MARIANA ERBIN, MARÍA JOSÉ ROLÓN
Published: 3 July 2023
http://www.doi.org/10.37201/req/042.2024
Introduction. Ceftazidime-avibactam (CZA) is a good option for Gram-negative bacilli infections that produce carbapenemase Classes A (especially blaKPC) and D (blaOXA). However, it is unknown whether it would have an impact on metallo-β-lactamases (blaMBL) selection. The aim of the study was to compare carbapenem and CZA Klebsiella pneumoniae (KPN) susceptibility profiles for a period of two years following the introduction of CZA.
Material and methods. The study was conducted in a 36-bed adult ICU of a tertiary hospital in Buenos Aires, Argentina. Antimicrobial consumption was expressed as days of treatment per 100 patients-day (DOT).
Results. A total of 123 KPN strains in the first year and 172 in the second year were analyzed. An alarming decrease in carbapenem susceptibility was detected in the second year (OR 0.5 [0.3-0.8] p<.001). In parallel, there was a decrease in CZA susceptibility (OR 0.5 [0.3-0.9] p<.05). These findings were linked to a rise in blaMBL-KPN (32.1% vs. 45.1%, OR 1.7 [1.1-2.9], p <.04) during the second year. This new KPN susceptibility profile promoted an increment in CZA (1.0 DOT vs. 6.6 DOT, OR 6.6 [4.9-9.1] p<.001) and aztreonam (0.3 DOT vs. 4.1 DOT, OR 16.3 [9.1-29.3] p<.001) consumption. Thus, there was a decrease in carbapenem prescription (17.8 DOT vs. 15.4 DOT, OR 0.8 [0.8-0.9] p<.001).
Conclusions. There was an escalation of blaMBL-KPN rate two years after CZA introduction, leading to a decrease in CZA and carbapenem susceptibility and an increase in CZA and aztreonam prescriptions.
Rev Esp Quimioter 2024; 37(5): 415-421 [Full-text PDF]
ALFREDO MALDONADO-BARRUECO, CLAUDIA SANZ-GONZÁLEZ, DAVID GRANDIOSO-VAS, IKER FALCES-ROMERO, JULIO GARCÍA-RODRÍGUEZ, INMACULADA QUILES-MELERO
Published: 1 July 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/030.2024
Rev Esp Quimioter 2024; 37(5): 425-426 [Full-text PDF]
ISABEL GUTIÉRREZ-MORALES, ANA LOZA-VÁZQUEZ, JOSÉ ANTONIO SÁNCHEZ-ROMÁN, ANTONIO GRILO-REINA, MARÍA ASUNCIÓN NAVARRO-PUERTO
Published: 28 June 2024
http://www.doi.org/10.37201/req/029.2024
Introduction. Our aim was to analyse the relation between serial values of the indocyanine green plasma disappearance rate (ICG-PDR) with hospital mortality in the first 48 hours of ICU admission in patients with septic shock.
Methods. A prospective observational study was carried out over 12 months of patients admitted to the ICU with septic shock. Each patient underwent noninvasive determination of ICG-PDR at 24 and 48 hours with the LiMON® module. Follow-up was performed until hospital discharge or exitus.
Results. 63 patients. Age 61.1±12.3 years. 60.3% men. SOFA score on admission 8.7±3.3, APACHE II score was 27.9±10.7 points. A total of 44.4% of patients died. The ICG-PDR values in the first 24 hours of ICU admission were lower in nonsurvivors: 10.5 (5.7-13.0)%/min vs. 15.9 (11.4-28.0)%/min, p <0.001. Furthermore, in nonsurvivors, there was no improvement in ICG-PDR between 24 h and 48 h, while in survivors, there was an increase of 25%: 15.9 (11.4-28.0)%/min and 20.9 (18.0-27.0)%/min, p=0.020. The silhouette measure of ICG-PDR cohesion and separation for the clusters analysed (nonsurvivors and survivors) was satisfactory (0.6). ICG-PDR<11.7%/min was related to in-hospital mortality, ICG-PDR> 18%/min to survival, and the interval between 11.7% and 18%/min covered a range of uncertainty. In the two-stage cluster, ICG-PDR, SOFA and APACHE II present satisfactory predictive scores 24 hours after patient admission.
Conclusions. ICG-PDR in our setting is a useful clinical prognostic tool and could optimise the decision tree in patients with septic shock.
Rev Esp Quimioter 2024; 37(5): 401-408 [Full-text PDF]
BELÉN CUADRADO GARCÍA, INÉS OLAYA GARCÍA RODRÍGUEZ, BEATRIZ CASTRO HERNÁNDEZ, RICARDO PELAZAS GONZÁLEZ, MARÍA LECUONA FERNÁNDEZ
Published: 27 June 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/041.2024
Rev Esp Quimioter 2024; 37(5): 429-431 [Texto completo PDF]
ALFREDO MALDONADO-BARRUECO, DAVID GRANDIOSO-VAS, MARIO RUIZ-BASTIÁN, JUANA CACHO-CALVO, CARLOS TORO, INMACULADA QUILES-MELERO
Published: 27 June 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/011.2024
Rev Esp Quimioter 2024; 37(5): 422-424 [Full-text PDF]
PATRICIA MUÑOZ, MARÍA GUEMBE, MARÍA JESÚS PÉREZ-GRANDA, JOSÉ LUÍS DEL POZO, LUIS EDUARDO LÓPEZ-CORTÉS, MAURO PITTIRUTI, MARÍA CRUZ MARTÍN-DELGADO, EMILIO BOUZA
Published: 26 June 2024
http://www.doi.org/10.37201/req/051.2024
Catheter-related infections (CRI) are a serious healthcare problem due to their potential to cause serious complications, including bacteraemia or infective endocarditis, and to increase patient morbidity and mortality. In addition, these in fections significantly prolong hospital stay and cost. Preventing CRI is crucial and is considered a criterion for quality and safety in healthcare.
For these reasons, the Spanish Society of Cardiovascular Infections (SEICAV) has considered it pertinent to review this topic, with experts in different areas including clinical microbiologists, infectious disease specialists, surgeons and nurses. The data were presented at a session held at the Ramón Areces Foundation, which was organised in the form of specific questions grouped into three round tables. The first panel analysed the scale of the problem including epidemiological, clinical and diagnostic aspects; the second panel addressed advances in the treatment of CRI; and the third panel reviewed developments in the prevention of CRI. The recorded session is available on the Areces Foundation website and we believe it maybe of interest not only to health professionals, but also to any non-expert citizen interested in the subject.
Rev Esp Quimioter 2024; 37(5): 387-400 [Full-text PDF]
