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Rev Esp Quimioter 2021;34(6):651-654

Comparison two blood culture bottles for the recovery of Enterobacteriaceae

ANA DE MALET, MARISOL GARCÍA-MERINO, SILVIA VELASCO, CARLOS RUIZ DE ALEGRÍA PUIG

Published: 13 September 2021

http://www.doi.org/10.37201/req/154.2020

Introduction. The objective of the present study was to compare the suitability of the B BACTEC™ Lytic/10 Anaerobic/F versus B BACTEC™ Plus Aerobic/F vials at the time of both Enterobacteriaceae recovery rate and detection time.
Material and methods. Prospective observational study from September 2018 to January 2019 in which 150 bacteremia. The samples were incubated in the automated BD BACTEC ™ FX system (Becton Dickison).
Results. A total of 180 Enterobacteriaceae were isolated: 93 B BACTEC™ Plus Aerobic/F and 87 from B BACTEC™ Lytic/10 Anaerobic/F belonging to 106 patients The urinary focus was the most frequent origin. The average detection time in both cases was not more than 15 hours.
Conclusion. The combination of both bottles seems to be the best diagnostic strategy, thus reducing the detection time as well as increasing the recovery of Enterobacteriaceae. The combination of both vials could be implemented especially in selected situation of special urgency such as the sepsis code or critical patients.

Rev Esp Quimioter 2021;34(6):651-654 [Full-text PDF]


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Rev Esp Quimioter 2021; 34(6):525-555

Overview of virus and cancer relationships. Position paper

EMILIO BOUZA, MIGUEL MARTÍN JIMÉNEZ, LAIA ALEMANY, JOAQUÍN ARRIBAS, RAFAEL BAÑARES, Mª BEGOÑA BARRAGÁN, JOSÉ MARÍA EIROS BOUZA, ENRIQUETA FELIP, OSCAR FERNÁNDEZ-CAPETILLO, DIEGO GRACIA, ROGELIO LÓPEZ-VÉLEZ, JUAN BAUTISTA MOLLAR, PATRICIA MUÑOZ, LUIS PAZ-ARES, AURELI TORNÉ, JAVIER TOVAR, EULALIA VALENCIA, ESTEBAN PALOMO

Published: 5 August 2021

http://www.doi.org/10.37201/req/058.2021

The role of certain viruses in the etiology of some tumors is today indisputable, but there is a lack, however, of annoverview of the relationship between viruses and cancer with amultidisciplinary approach. For this reason, the Health Sciences Foundation has convened a group of professionals from different areas of knowledge to discuss the relationship between viruses and cancer, and the present document is the result of these deliberations. Although viruses cause only 10-15% of cancers, advances in oncology research are largely due to the work done during the last century on tumor viruses. The clearest cancer-inducing viruses are: HPV, HBV, HCV, EBV and, depending on the geographical area, HHV-8, HTLV-1 and HIV. HPVs, for example, are considered to be the causative agents of cervical carcinomas and, more recently, of a proportion of other cancers. Among the Herpes viruses, the association with the development of neoplasms is well established for EBV and HHV-8. Viruses can also be therapeutic agents in certain neoplasms and, thus, some oncolytic viruses with selective tropism for tumor cells have been approved for clinical use in humans. It is estimated that the prophylaxis or treatment of viral infections could prevent at least 1.5 million cancer deaths per year.

Rev Esp Quimioter 2021; 34(6):525-555 [Full-text PDF]


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Rev Esp Quimioter 2021; 34(4): 289-297

Safety in the selection of oral antibiotic treatment in community infections, beyond COVID-19

JOSÉ BARBERÁN, LOURDES CRISTINA BARBERÁN, ALICIA DE LA CUERDA

Published: 28 July 2021

http://www.doi.org/10.37201/req/087.2021

Oral antibiotics are among the most frequently used medications in the community. Its adverse effects are generally considered to be infrequent and mild, and include allergies, toxicities and drug interactions. Antibiotics are able to harm patients by various mechanisms, not always well known. Knowledge of the clinically relevant antibiotic-associated adverse effects can allow a judicious use based on the principle
first do no harm, primun non nocere. In this review we explore the main adverse effects of oral antibiotics with specific focus on β-lactams, macrolides, and fluoroquinolones.

Rev Esp Quimioter 2021; 34(4): 289-297 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5):509-510

Artritis meningocócica primaria

ESTIBALIZ ERVITI MACHAIN, AITZIBER AGUINAGA PÉREZ, ANA NAVASCUÉS ORTEGA, CARMEN EZPELETA BAQUEDANO

Published: 26 July 2021

LETTER TO THE EDITOR

http://www.doi.org/10.37201/req/056.2021

Rev Esp Quimioter 2021;34(5):509-510 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5):483-490

Prospective study of the incidence density of multi-resistant microorganisms and Clostridioides difficile during the period 2012- 2019 in the Canary Islands

ALEJANDRO DE ARRIBA-FERNÁNDEZ, MANUEL JESÚS MOLINA-CABRILLANA, LLUÍS SERRA-MAJEM, PALOMA GARCÍA-DE CARLOS

Published: 26 July 2021

http://www.doi.org/10.37201/req/046.2021

Introduction. In 2012, the Canary Islands Health Service implemented a new surveillance system for nosocomial infections caused by multi-resistant microorganisms and Clostridioides difficile. This system will make it possible to know the incidence rates of these pathogens, periodically contrast them to monitor their trend and compare them with those of other national and European health institutions.
Patients and method. Observational, prospective study of the density of incidence of multi-resistant pathogens and Clostridioides difficile in the healthcare centers of the Canary Islands Health Service from 2012 to 2019.
Results. The incidence density of methicillin-resistant Staphylococcus aureus infections for 2012 was 1.96 cases per 10,000 stays and decreased to 0.80 in 2019, reaching the lowest figure in the surveillance period. Infections due to carbapenemase-producing Enterobacterales (CPE) showed an upward trend, 0.47 (2014) and 2.35 (2019). The slight upward trend in imipenem-resistant Acinetobacter baumannii infections in observed bacteraemias 0.17 (2012) and 0.09 (2019) has been corrected. No cases of infection with vancomycin-resistant enterococci were observed. With regard to C. difficile, an upward trend that began in 2012 has consolidated, producing an increase of 216% in the number of cases detected at the end of the study period.
Conclusion. The most relevant problem detected today is the CPE. The data analyzed in this period showed an evident change in the trend of the multi-resistant pathogens studied. This fact must be confirmed in the future.

Rev Esp Quimioter 2021;34(5):483-490 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5) 496-499

Mycoplasma genitalium in Primary Care: Prevalence and azithromycin resistance in Santiago de Compostela Health Care Area

MERCEDES TREVIÑO, MARÍA RODRÍGUEZ-VELASCO, TAMARA MANSO, MARÍA CEA

Published: 21 July 2021

http://www.doi.org/10.37201/req/052.2021

Objectives. Mycoplasma genitalium is associated with persistent/recurrent sexually transmitted infections. The aim of this work was to estimate the prevalence and azithromycin resistance of M. genitalium in general population that was attended at Primary Care of Santiago de Compostela Health Care Area.
Material and methods. The study was carried out in 2019 in general population of Santiago de Compostela Health Care Area. Real-time multiplex PCR was used for screening of sexually transmitted infections associated pathogens and detection of mutations in the 23S rRNA gene.
Results. A total of 502 women and 532 men were studied. The prevalence of M. genitalium was 2,4% in men and 2,9% in women. Overall azithromycin resistance was 20% all of them detected in men. The mutations found were A2059G, A2058G and A2058T.
Conclusions. Although the proportion of M. genitalium infection is low, the high percentage of azithromycin resistance detected supports the relevance of these data in order to the right management of the patients with sexually transmitted diseases and, so as, to avoid the emergence of resistance in other pathogens of the urogenital tract.

Rev Esp Quimioter 2021;34(5) 496-499 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5):491-495

Pneumonia in patients with SARS-CoV-2 infection: series of 17 cases in the region of Murcia

ENCARNACIÓN MORAL ESCUDERO, ALICIA HERNÁNDEZ TORRES, AYCHEL ELENA ROURA PILOTO, HELENA ALBENDÍN IGLESIAS, ANA PELÁEZ BALLESTA, ELISA GARCÍA VÁZQUEZ Y GRUPO DE ESTUDIO COVID

Published: 16 July 2021

http://www.doi.org/10.37201/req/151.2020

Introduction. Currently the prevalence of pneumococcal coinfection in patients with COVID-19 is unknown. In this work we present its clinical characteristics, evolution and treatment.
Material and methods. Retrospective data collection from August to October 2020 in two hospitals in the Murcia region.
Results. Eighteen patients had COVID-19 diagnosed by PCR and pneumococcal infection confirmed by antigenuria, which represented a prevalence of 2%. A total of 88% had radiological alterations upon admission (two patients had an X-ray within normality) and 29% had elevated procalcitonin. Mortality in our series was 12%.
Conclusions. It could be reasonable to consider the start of antimicrobial therapy in those cases in which there is a moderate or high suspicion of bacterial coinfection, being essential the early suspension of antibiotic treatment if it is not confirmed.

Rev Esp Quimioter 2021;34(5):491-495 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(6):556-568

Influenza and cardiorespiratory events: a clinical-epidemiological review with a multidisciplinary point of view

AMELIA CARRO HEVIA, FRANCISCO SANZ HERNÁNDEZ, JAVIER ÁLVAREZ ALDEÁN, MANUEL GARCÍA CENOZ, ISABEL JIMENO SANZ, ESTHER REDONDO MARGÜELLO, Mª TERESA VIDÁN ASTIZ, AMÓS GARCÍA ROJAS

Published: 14 July 2021

http://www.doi.org/10.37201/req/065.2021

There is accumulating evidence showing that influenza infection and cardiorespiratory diseases are closely associated. Influenza has been described as a triggering factor capable of both exacerbate underlying chronic diseases as well as inducing the appearance of new respiratory and cardiovascular events. Consequently, influenza infection and its associated comorbidity have a significant impact on the health system. In this document, we extensively reviewed the current literature to describe the most relevant data on the relationship between influenza infection and cardiorespiratory diseases. Likewise, we analyzed the possible pathophysiological mechanisms explaining the connection between influenza infection and cardiac and respiratory events. Finally, reviewed data has been put into perspective to highlight the importance of influenza vaccination as an effective measure in the prevention of cardiorespiratory diseases, especially in the population with underlying chronic diseases.

Rev Esp Quimioter 2021;34(6):556-568 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5):502-503

Síndrome de cola de caballo en paciente VIH

LARA MUÑOZ-MUÑOZ, ANTONIO BELTRÁN-ROSEL, Mª ASUNCIÓN VITORIA-AGREDA, Mª JOSÉ CRUSELLS-CANALES

Published: 12 July 2021

http://www.doi.org/10.37201/req/039.2021

LETTER TO THE EDITOR

Rev Esp Quimioter 2021;34(5):502-503 [Texto completo PDF]


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Rev Esp Quimioter 2021;34(5):504-505

Bacteriemia por nocardiosis pulmonar diseminada

ESPERANZA LEPE-BALSALOBRE, RICARDO RUBIO-SÁNCHEZ, ROCÍO CABRA-RODRÍGUEZ

Published: 7 July 2021

http://www.doi.org/10.37201/req/040.2021

LETTER TO THE EDITOR

Rev Esp Quimioter 2021;34(5):504-505 [Texto completo PDF]


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