Rev Esp Quimioter 2022;35(Suppl.3):63-66

Norovirus infection as a model of chronic or recurrent infection in common variable immunodeficiency

PEDRO MORAL MORAL, DAFNE CABAÑERO-NAVALON, VICTOR GARCIA-BUSTOS, MARÍA NÚÑEZ BELTRÁN, MIGUEL SALAVERT LLETÍ

Published: 24 October 2022

http://www.doi.org/10.37201/req/s03.14.2022

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency (PID) in general population. PID are genetic diseases that share a dysfunction in the immune system entailing a greater risk of both chronic and recurrent infections. These patients can also develop chronic gastrointestinal infections caused by norovirus with persistent viral dissemination, which can be detected months after primoinfection. Additionally, a proportion of CVID patients show a typical severe enteropathy presenting with recurrent diarrhoea, intestinal malabsorption, inflammatory lesions, and villous atrophy. Some studies have related this enteropathy with chronic intestinal infection caused by norovirus.

Rev Esp Quimioter 2022; 35(Suppl.3):63-66 [Full-text PDF]