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Rev Esp Quimioter 2024, 37(4): 356-359

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid

LUIS ALOU, ELENA GÓMEZ-RUBIO, MARÍA-JOSÉ GIMÉNEZ MESTRE, FRANCISCO-JAVIER ALVARO-AFONSO, PILAR CORONEL, DAVID SEVILLANO

Published: 13 June 2024

http://www.doi.org/10.37201/req/028.2024

Skin and soft tissue infections (SSTIs), and particularly diabetic-related foot infections (DFI), present diagnostic and therapeutic complexities, often leading to severe complications. This study aims to evaluate the in vitro efficacy of cefditoren and amoxicillin/clavulanic acid against typical DFI pathogens. Clinical samples from 40 patients with mild SSTIs were analyzed, revealing a predominance of Staphylococcus spp. and Streptococcus spp. species. Cefditoren exhibited activity against 90% of isolates, with superior potency over amoxicillin/clavulanic acid. These findings underscore the utility of cefditoren in empirical treatment of DFI, although a larger sample size would be desirable for further validation.

Rev Esp Quimioter 2024; 37(4): 356-359 [Full-text PDF]


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