Rev Esp Quimioter 2024, June 13
Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid
LUIS ALOU, ELENA GÓMEZ-RUBIO, MARÍA-JOSÉ GIMÉNEZ MESTRE, FRANCISCO-JAVIER ALVARO-AFONSO, PILAR CORONEL, DAVID SEVILLANO
Published: 13 June 2024
http://www.doi.org/10.37201/req/028.2024
Skin and soft tissue infections (SSTIs), and particularly diabetic-related foot infections (DFI), present diagnostic and therapeutic complexities, often leading to severe complications. This study aims to evaluate the in vitro efficacy of cefditoren and amoxicillin/clavulanic acid against typical DFI pathogens. Clinical samples from 40 patients with mild SSTIs were analyzed, revealing a predominance of Staphylococcus spp. and Streptococcus spp. species. Cefditoren exhibited activity against 90% of isolates, with superior potency over amoxicillin/clavulanic acid. These findings underscore the utility of cefditoren in empirical treatment of DFI, although a larger sample size would be desirable for further validation.
Rev Esp Quimioter 2024; June 13 [Full-text PDF]
