Rev Esp Quimioter 2019; 32(3):238-245

Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital

FERNANDO RAMASCO, ANGELS FIGUEROLA, ROSA MENDEZ, DIEGO RODRÍGUEZ SERRANO, ANDRÉS VON WERNITZ, ANA HERNÁNDEZ-ACEITUNO, CARMEN SÁEZ, LAURA CARDEÑOSO, ELENA MARTIN, NIEVES GARCÍA-VÁZQUEZ, CARMEN DE LAS CUEVAS, NATALIA PASCUAL, AZUCENA BAUTISTA, DAVID JIMÉNEZ, GUILLERMO FERNÁNDEZ, ANA LEAL, MERCEDES VINUESA, ALBERTO PIZARRO, MARCELLO DI MARTINO, LOURDES DEL CAMPO, IÑIGO GARCÍA SANZ, MARTA CHICOT, ANA BARRIOS, MARÍA JOSÉ RUBIO, THE MEMBERS OF DE CODE SEPSIS H.U DE LA PRINCESA

Objectives. To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors.
Materials and methods. A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 – September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses.
Results. A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05).
Conclusions. The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs.

Rev Esp Quimioter 2019; 32(3):238-245 [Full-text PDF]