Endotoxin adsortion as adjuvant therapy in gramnegative severe sepsis F.J. CANDEL, F. MARTÍNEZ-SAGASTI, M. BORGES, E. MASEDA, M. HERRERA-GUTIÉRREZ, J. GARNACHO-MONTERO, F.J. MAYNAR, R. ZARAGOZA, J. MENSA, J.R. AZANZA The mortality rate of severe sepsis and septic shock remains still high. Within the last years a better knowledge of its physiopathology and the implementation […]
Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates A. J. CARRILLO-MUÑOZ, C. TUR-TUR, J. M. HERNÁNDEZ-MOLINA, G. QUINDÓS, C. MARCOS-ARIAS, E. ERASO, D. CÁRDENES, O. ORTIZ-MAESTRO, P. SANTOS, D. ESTIVILL, C. GUARDIA, G. GIUSIANO The in vitro antifungal activity of posaconazole was tested against 315 yeast clinical isolates and 11 […]
Critical study of spanish adult consumer profile of antibiotics on the basis of National Surveys of Health in 1993, 1995, 1997, 2001 and 2003 J. L. BAQUERO, J. BARBERÁN, D.MARTÍNEZ Objective: The objective of this study has been to examine antibiotic consumption in Spain through the use of the National Surveys of Health (NSH) […]
Impact factor and quality of scientific publications on Microbiology: the example of the Spanish Journal of Chemotherapy D. CARABANTES Introduction. The impact factor of a journal is the quantitative analysis of the number of citations obtained during a specific period of time. This currently is the standard tool to measure the quality of the […]
Comparative activity of doripenem, meropenem, and imipenem in recent clinical isolates obtained during the COMPACT-Spain epidemiological surveillance study C. GIMENO, R. CANTÓN, A. GARCÍA, M. GOBERNADO Y GRUPO ESPAÑOL DE ESTUDIO DE DORIPENEM Introduction. Doripenem is a new carbapenem with broad spectrum antibacterial activity indicated for the treatment of nosocomial pneumonia and complicated urinary […]
Nosocomial candidemia: new challenges of an emergent problem J. GÓMEZ, E. GARCÍA-VAZQUEZ, A. HERNÁNDEZ, C. ESPINOSA, J. RUIZ GÓMEZ Candida spp. are currently one of the most common causes of bloodstream infections in hospitals. Over the last two decades there has been a shift towards a greater involvement of non-Candida albicans as the cause of […]
Antifungal agents in the treatment of systemic infections: Relevance of mechanism of action, activity profile and resistances M. CUENCA-ESTRELLA The availability of different therapeutic alternatives has modified the treatment of systemic fungal infections. There commendations of antifungal therapy vary according to species which causes the mycosis and its susceptibility. Consequently, the knowledge of action […]
Prophylaxis and treatment of invasive fungal infection in neutropenic patients C. VALLEJO, M. ROVIRA Prophylaxis and treatment constitute the basis for reducing the mortality due to IFI. Prophylaxis is currently the standard practice in most hospitals and is recommended by the principal guidelines. Fluconazole has proved to be useful to prevent and reduce the mortality […]
Experience of micafungin in patients requiring extrarenal depuration F. ALVAREZ-LERMA, S. GRAU, Y. DÍAZ, J. FERNÁNDEZ Introduction. The use of extrarenal depuration techniques is increasingly frequent in patients admitted to the ICU. The use of these procedures has been related to a decrease in plasma concentrations of several antimicrobials, among which fluconazole. The activity […]
Significance of lower respiratory tract cultures yielding Aspergillus spp. growth in a hospital without transplant patients P. LUCENA, J. BARBERÁN, G. EROLES, J. J. GRANIZO, M. J. GIMÉNEZ, N. MIR, L. AGUILAR, J. PRIETO Introduction: Isolation of Aspergillus spp. in non-neutropenic, non-transplant patients with chronic obstructive pulmonary disease (COPD) usually treated with corticosteroids is […]
