Rev Esp Quimioter 2021; 34(4): 308-314

Prognostic value of static and dynamic biomarkers in COVID-19 patients: a prospective cohort study

MACARENA HORMANSTORFER, HÉCTOR BORODOWSKI, KEVIN NELSON, MARÍA JAZMÍN PATROSSO, INGRID KOLLAND, LUCA ITALIANO, VERÓNICA INÉS CASALI, PALOMA VICTORIA BARRIOS, LUIS FELIPE HERNÁNDEZ SEPULVEDA, MARÍA EUGENIA TANARO, CYNTHIA ALDANA PETRAGLIA, ALEXIA DENISSE AGUZEZKO, CECILIA LUNA, CARLOS MOUSE, IGNACIO GANDINO, JOSE LUIS PRESAS, FRANCISCO PAULIN

Published: 31 May 2021

http://www.doi.org/10.37201/req/141.2020

Objective. The aim of this study was to analyze in a prospective cohort of hospitalized COVID-19 patients the relationship between biomarkers levels and their variation within the first 4 days since admission, and prognosis.
Material and methods. Prospective cohort study. Individuals with confirmed diagnosis of covid-19 admitted in our hospital were included. Blood samples were obtained systematically on days 1 and 4 of hospitalization. Levels of RCP, LDH, Ferritin and D-dimer, together with platelets, lymphocytes and neutrophils counts were measured. A combined outcome that included ICU admission and death was considered the primary outcome. Logistic regression analysis was performed.
Results. We included 335 patients with confirmed COVID-19. During their hospitalization, 23 (6.8%) needed ICU admission, and 10 (2.9%) died. In the multivariate analysis, a value of RCP greater than 10 mg/dl (OR 8.69, CI95% 1.45-52), an increase in RCP greater than 20% (OR 26.08, CI 95% 3.21-211.3), an increase in LDH greater than 20% (OR 6.29, CI 95% 1.84-21.44), a count of lymphocytes lower than 1500/mm3 (OR 2.74, CI 95% 1.04-7.23), a D-dimer value greater than 550 ng/ml (OR 9.8, CI 95% 1.78-53.9) and a neutrophil/lymphocyte index greater than 3(OR 4.5, CI 95% 1.43-14.19) were all associated with the primary outcome.
Conclusion. Our study shows that the utilization of static and dynamic biomarkers may represent an important tool to assess prognosis of COVID-19 patients.

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Rev Esp Quimioter 2021; 34(4): 308-314 [Full-text PDF] [Supplementary material PDF]