BELÉN GONZÁLEZ FERNÁNDEZ, SONSOLES GARCINUÑO PÉREZ, LAURA SÁNCHEZ-DE PRADA, IGNACIO EIROS-BACHILLER, JOSÉ ANTONIO BRIZUELA SANZ, JOSÉ M. EIROS
Published: 20 February 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/135.2023
Rev Esp Quimioter 2024; 37(2): 193-195 [Texto completo PDF]
JESÚS RUIZ RAMOS, ANA SUÁREZ-LLEDÓ GRANDE, MARÍA ROSARIO SANTOLAYA PERRÍN, CARMEN CABALLERO REQUEJO, MARIAM HIJAZI VEGA, LAIA LÓPEZ VINARDELL, ÁNGELES GARCÍA MARTÍN, YLENIA CAMPOS BAETA, ANA JOSEFA MARCOS GONZÁLEZ, MONTSERRAT ALONSO DÍEZ, SILVIA CONDE GINER, SAÚL HERRERA CARRANZA, ANA SUCH DIÁZ, MARGARITA PRATS RIERA, LARA MENENDEZ LIENDO, CRISTINA TORO BLANCH, ANA REVUELTA AMALLO, CRISTINA CALZÓN BLANCO, EN REPRESENTACIÓN DEL GRUPO PROA-URGENCIAS
Published: 19 February 2024
http://www.doi.org/10.37201/req/138.2023
Introduction. Antimicrobial stewardship programs (ASP) have become a key tool in the adaptation of these drugs to the health system. The information available on the application and indicators used in these programs in emergency departments is scarce. The objective of this study is to know the extent of ASP implementation in the emergency departments, as well as the use of antimicrobials in these units.
Material and methods. Multicenter retrospective study. An invitation was sent to all participants of the REDFASTER-SEFH emergency pharmacist working group. A questionnaire was used consisting of 21 items, answered by a team made up of a pharmacist, emergency room specialist, infectious disease specialist and microbiologist.
Results. Eighteen hospitals completed the survey. Fourteen (77.8%) had an ASP manager. The DDD value per 1000 admissions ranged between 36.5 and 400.5 (median: 100.4 [IQR:57.2-157.3]). Both carbapenem and macrolide group presented wide variability in use. Six (33.3%) hospitals had an annual report on the specific resistance profile for urine and blood cultures. The percentage of multi-drug resistant strains in urine cultures was 12.5% and in blood cultures 12.2%. The percentage of adequacy in the bacteremia treatment was 81.0% (IQR:74.6-85.0%), while in urinary tract infections was 78.0% (IQR:71.5-88.0).
Conclusions. Despite the existence of ASP members in emergency services, as well as the training activity and local guidelines is common. knowledge of the use of antimicrobials and resistances is limited. Future activities must be aimed at improving information about the ASP results in these units.
Rev Esp Quimioter 2024; 37(2): 163-169 [Texto completo PDF]
EDUARDO RUBIO-MORA, JUANA CACHO-CALVO, INMACULADA QUILES MELERO
Published: 13 February 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/132.2023
Rev Esp Quimioter 2024; 37(2): 191-192 [Full-text PDF]
ISABEL RAMOS, ADELA BENÍTEZ-CANO, SONIA LUQUE, LUISA SORLÍ, RAMON ADALIA
Published: 13 February 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/131.2023
Rev Esp Quimioter 2024; 37(2): 189-190 [Texto completo PDF]
JOSÉ MARÍA SERRANO-ROMERO, ANA ROMÁN-DE-LA-TORRE, JOSÉ MARÍA NAVARRO-MARÍ, JOSÉ GUTIÉRREZ-FERNÁNDEZ
Published: 13 February 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/128.2023
Rev Esp Quimioter 2024; 37(2): 186-188 [Texto completo PDF]
ELENA HERRANZ-BAYO, RAFAEL HUARTE-LACUNZA, PILAR SÁNCHEZ-CHUECA, IRENE AGUILÓ-LAFARGA, ANDREA PINILLA-RELLO, EVA SAMPEDRO-CALAVIA
Published: 9 February 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/120.2023
Rev Esp Quimioter 2024; 37(2): 183-185 [Texto completo PDF]
LAURA RITA IOTTI, MÓNICA DE FRUTOS, BELÉN LORENZO-VIDAL, JOSÉ M. EIROS
Published: 30 January 2024
LETTER TO THE EDITOR
http://www.doi.org/10.37201/req/119.2023
Rev Esp Quimioter 2024; 37(2): 180-182 [Texto completo PDF]
JORGE LIGERO-LÓPEZ, IKER FALCES-ROMERO, ALFONSO ARANDA-DÍAZ, DIANA GARCÍA-BALLESTEROS, JULIO GARCÍA-RODRÍGUEZ, EMILIO CENDEJAS-BUENO
Published: 8 November 2023
http://www.doi.org/10.37201/req/043.2023
The new automated systems designed for rapid performance of AST have significantly reduced the response time for susceptibility testing of microorganisms causing bacteremia and sepsis. The Accelerate Pheno® system (AAC) is one such system. Our objective for this study was to determine whether the AAC system is capable of providing an accurate susceptibility profile to infer resistance mechanisms in different carbapenemase-producing isolates when compared to the MicroScan WalkAway System (MWS). Disk diffusion method was also performed on all isolates as a reference method. Additionally, we compared the results obtained with the routine AST production system. We selected 19 isolates from the cryobank of the Microbiology department, all of which were carbapenemase-producing gram-negative bacilli. AAC was able to identify and infer the resistance of a total of 10 isolates, with an EA and CA of 84.2% for meropenem and 88.2% and 64.7% for ertapenem EA and CA, respectively. If we consider the disk diffusion technique, the CA was 57.9% and 76.5% for meropenem and ertapenem. However, in the presence of carbapenemases, AAC was not able to provide adequate MICs or infer the resistance mechanisms of the isolates accurately. Further studies with a larger number of isolates, including the new antibiotics ceftolozane/tazobactam and ceftazidime/avibactam, are needed for a more comprehensive comparison.
Rev Esp Quimioter 2024;37(1): 88-92 [Full-text PDF]
JORGE LIGERO-LÓPEZ, LUIS ESCOSA-GARCÍA, CRISTINA SCHÜFFELMANN-GUTIÉRREZ, MARÍA LAPLAZA-GONZÁLEZ, MARÍA INMACULADA QUILES-MELERO, FRANCISCO MORENO-RAMOS, FERNANDO BAQUERO-ARTIGAO, JUANA CACHO-CALVO, EMILIO CENDEJAS-BUENO
Published: 23 January 2024
http://www.doi.org/10.37201/req/116.2023
Objectives. Our observational, retrospective study aimed to determine the correlation between bacteria isolated from bronchial aspirates of pediatric ICU patients (PICU) with respiratory infections and those obtained from conjunctival swabs of the same patients exhibiting clinical conjunctivitis.
Material and methods. Throughout the period from 2015 to 2022, we reviewed all clinically significant bronchial aspirates (≥105 CFU/mL) and positive conjunctival swabs obtained from PICU patients. These records were retrieved from the microbiology database, cross-referencing the data to identify patients who tested positive for both during the same clinical episode.
Results. The median age of the patients was 5 months (interquartile range: 1-7). Among the cohort, twenty-one patients exhibited positivity in both bronchial aspirate and conjunctival swab samples, showcasing a microbial match in 85.71% of cases (18 out of 21). The most frequently isolated microorganisms were Haemophilus influenzae (55.6%), followed by Pseudomonas aeruginosa (14.3%), Klebsiella aerogenes (9.5%), and Escherichia coli, Stenotrophomonas maltophilia, and Enterobacter cloacae, each accounting for 4.8% of the isolates.
Conclusions. Our study demonstrates a strong concordance between the isolated microorganisms from both samples in patients presenting clear symptoms of clinical conjunctivitis. These findings provide a basis for future prospective studies that may leverage conjunctival swabs as a predictive tool for identifying microorganisms involved in respiratory infections.
Rev Esp Quimioter 2024; 37(2): 176-179 [Full-text PDF]
PAULA MARÍN OLIVÁN, SUSANA FERRANDO MONLEÓN, JOSÉ RAFAEL BRETÓN-MARTÍNEZ, ANDRÉS PIOLATTI LUNA, IDOIA HERNÁNDEZ MONLEÓN, CRISTINA FUERTES LATASA, DAVID NAVARRO ORTEGA, JAVIER COLOMINA RODRÍGUEZ
Published: 22 January 2024
http://www.doi.org/10.37201/req/113.2023
Introduction. The objectives of this work were to know the prevalence of methicillin-resistant S. aureus (MRSA) infections in the paediatric population of our health department, to describe the risk factors for infection by MRSA compared to those produced by methicillin-susceptible S. aureus (MSSA) and to know the antibiotic sensitivity profile of MRSA and MSSA isolates.
Material and methods. A retrospective, descriptive and analytical study of infections produced by MRSA versus those produced by MSSA was carried out during the years 2014 to 2018. Risk factors for MRSA infection were studied using a binary logistic regression model.
Results. 162 patients with S. aureus infections were identified. Of these, 25 (15.4%) were MRSA. The highest percentages of MRSA infection occurred among children who required hospital admission (23.4%). In the univariate analysis the need of hospital admission, antibiotic treatment in the last 3 months, the kind of infection and past MRSA infection or colonisation reached statistical significance. However, only the need of hospital admission and antibiotic treatment in the last 3 months maintained statistical significance in the binary logistic regression model. Correct antibiotic treatment was only prescribed in 26.7% of the MRSA infection cases admitted to the hospital.
Conclusions. Our results suggest the need to review empirical local treatment regimen using drugs active against MRSA in infections of probable staphylococcal origin admitted to the hospital, especially if they have received antibiotic treatment in the last 3 months.
Rev Esp Quimioter 2024; 37(2): 170-175 [Texto completo PDF]
